An Open-Source Wireless Electrophysiology System for In Vivo Neuronal Activity Recording in the Rodent Brain: 2.0.

Current trends in neurobiological research focus on analyzing complex interactions within brain structures. To conduct relevant experiments, it is often essential to employ animals with unhampered mobility and utilize electrophysiological equipment capable of wirelessly transmitting data. In prior research, we introduced an open-source wireless electrophysiology system to surmount these challenges.

Positive Allosteric Modulators of SERCA Pump Restore Dendritic Spines and Rescue Long-Term Potentiation Defects in Alzheimer's Disease Mouse Model.

Alzheimer's disease (AD) is a neurodegenerative disorder that affects memory formation and storage processes. Dysregulated neuronal calcium (Ca) has been identified as one of the key pathogenic events in AD, and it has been suggested that pharmacological agents that stabilize Ca neuronal signaling can act as disease-modifying agents in AD. In previous studies, we demonstrated that positive allosteric regulators (PAMs) of the sarco/endoplasmic reticulum Ca ATPase (SERCA) pump might act as such Ca-stabilizing agents and exhibit neuroprotective properties.

[EXPERIENCE WITH E. COLI LYOPHILIZED BACTERIAL LYSATE OM-89 (URO-VAKSOM®) IN MEN WITH ASYMPTOMATIC BACTERIOSPERMIA].

Chronic prostatitis is a significant problem of modern urology because it is the most common urological disease among the male population. We consider a 3 month course of OM-89 (Uro-Vaksom®) the most rational treatment of asymptomatic bacteriospermia caused by not only E. coli, but also by coexisting bacteria.

[Experience in the treatment of autoimmune male infertility in patients with category 4 chronic prostatitis].

Administration of longidaza at a dose of 3000 IU intramuscularly twice a week after 1 month of treatment leads to the statistically significant reduction of antisperm antibodies (ASAB) at the surface of sperm cells to 23% (7-48%) for MARIgG and to 14.5% (3-34%) for MARIgA. Maximum reduction of ASAB, however, was observed after third month of treatment, mean MARIgG was 2% (1-26,5%) and MARIgA - 1% (0-11.