Publications by authors named "E Joosens"

Article Synopsis
  • The study aimed to assess the safety and tolerability of an individualized starting dose (ISD) of niraparib in patients with newly diagnosed advanced ovarian cancer who responded to platinum-based chemotherapy.
  • An analysis of treatment-emergent adverse events (TEAEs) revealed that common side effects occurred early, with hematologic TEAEs resolving in over 89% of patients within a median duration of about 2 weeks.
  • Overall, the niraparib ISD was found to be well tolerated, indicating the importance of close monitoring after starting treatment and helping set patient expectations regarding safety.
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Purpose: Evaluate the efficacy of a novel skincare product for the management of chemotherapy-related dermatological toxicities.

Methods: A monocentric, prospective, interventional, open-label, pretest-posttest, single-group study with cancer patients receiving chemotherapy (n = 100) was set up. All enrolled patients applied the emollient daily to their face and body for three weeks.

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The paranasal sinuses are rarely the site of malignancy, especially non-Hodgkin lymphoma. In such cases, the ethmoid sinus is the second most frequently involved paranasal sinus. Diagnosis of these malignancies is difficult because the early symptoms often mimic benign sinus pathology.

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Bevacizumab (BEV) has demonstrated anti-tumor activity in patients with recurrent glioblastoma (rGB). Given the unmet need for active therapeutic options in rGB patients, a medical need program was initiated by the Belgian competent authorities. Between November 2010 and February 2013, a total of 313 patients with rGB initiated treatment with BEV administered at a dose of 10 mg/kg every 2 weeks.

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Temozolomide (TMZ) is an alkylating agent, used for the treatment of high-grade gliomas. This case report describes the development of a non-Hodgkin lymphoma in a patient treated with extended-dose temozolomide and radiotherapy. In addition to the possible mutagenic effect of temozolomide - as described for all alkylating agents - there might have been an immunosuppressive effect of TMZ.

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