Publications by authors named "E Joe Moran"
Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that generates more DNA damage in the tumor than standard radiotherapy using photons. Two human BRCA1-mutated breast cancer cell lines and their isogenic BRCA1-recovered pairs were treated with a PARP inhibitor and irradiated with photons or protons.
View Article and Find Full Text PDFWe present a radiative cooling material capable of enhancing albedo while reducing ground surface temperatures beneath fielded bifacial solar panels. Electrospinning a layer of polyacrylonitrile nanofibers, or nanoPAN, onto a polymer-coated silver mirror yields a total solar reflectance of 99 %, an albedo of 0.96, and a thermal emittance of 0.
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- The study focuses on creating a software tool for doctors to predict ovulation timing and evaluate how this affects pregnancy rates in natural cycle frozen embryo transfers (NC-FET).
- Three datasets were analyzed to develop and validate an ovulation prediction model, achieving high accuracy rates (93.85% and 92.89%) in predicting ovulation.
- The results showed that patients who followed the model's predictions had significantly better clinical pregnancy rates compared to those who did not, especially in women under 37 years old.
Revefenacin Area Under the Curve Spirometry in Patients with Moderate to Very Severe COPD.
Int J Chron Obstruct Pulmon Dis
October 2024
Purpose: Several lung function endpoints are utilized in clinical trials of inhaled bronchodilators for chronic obstructive pulmonary disease (COPD). Trough forced expiratory volume in 1 second (FEV) is a commonly reported endpoint in COPD trials and can be complemented by area under the FEV vs time curve (FEV AUC), which provides information on duration and consistency of bronchodilation over a dosing interval. Revefenacin, a once-daily bronchodilator, significantly improved lung function in patients with COPD when measured by trough FEV in two replicate Phase 3 trials.
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- Retinal hypoxia is a key but often overlooked factor in the development and progression of several retinal disorders, including glaucoma and diabetic retinopathy.
- Currently available treatments focus on managing symptoms rather than directly targeting the underlying issue of hypoxia.
- There is a growing need for new therapeutic strategies that directly address retinal hypoxia, supported by advancements in technology, to improve outcomes for patients facing vision loss.