Publications by authors named "E Jimenez Villa"
Liver transplantation (LT) is a curative strategy for hepatocellular carcinoma (HCC), but the risk of HCC recurrence remains a challenging problem. In patients with HCC recurrence after LT (HCC-R_LT), the locoregional and surgical approaches are complex, and the guidelines do not report evidence-based strategies for the management of immunosuppression. In recent years, immunotherapy has become an effective option for patients with advanced HCC in pre-transplant settings.
View Article and Find Full Text PDFPhase separation is an important mechanism to generate certain biomolecular condensates and organize the cell interior. Condensate formation and function remain incompletely understood due to difficulties in visualizing the condensate interior at high resolution. Here we analyzed the structure of biochemically reconstituted chromatin condensates through cryo-electron tomography.
View Article and Find Full Text PDFBackground: Tethering is a common condition of the mitral valve apparatus in the presence of significant regurgitation. Its impact on outcomes of transcatheter edge-to-edge repair (TEER) remains poorly characterized.
Methods: We appraised the prevalence, features, procedural details, and outcomes of patients with or without mitral valve tethering in a prospective multicenter observational study.
Article Synopsis
- Aortic valve replacement (AVR) has seen an increased use of the Perceval sutureless bioprosthesis, which shows promising safety and reliability in both short- and mid-term outcomes, with some long-term data emerging.
- An updated systematic review of studies from 2015 to 2024 analyzed long-term outcomes of 5,221 patients with Perceval implants, revealing a long-term survival rate between 64.8% to 87.9% and low rates of complications such as structural valve degeneration and significant leaks.
- Despite limited data on sutureless bioprostheses, the encouraging results from existing studies suggest that Perceval could provide
Article Synopsis
- Balloon-expandable valves (BEVs) and self-expanding valves (SEVs) are compared for their effects on patients with Sievers type 1 bicuspid aortic valve (BAV) stenosis undergoing transcatheter aortic valve replacement.
- The analysis, based on a registry of 955 patients, found no significant difference in midterm major adverse events or technical success between BEVs and SEVs after adjusting for baseline differences.
- However, BEVs had lower risks of new permanent pacemaker implantation and moderate or greater paravalvular regurgitation, but a higher risk of severe patient-prosthesis mismatch compared to SEVs.