Publications by authors named "E Jimenez Balderas"
Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease.
Physiology (Bethesda)
September 2024
Article Synopsis
- Oxidative phosphorylation, vital for energy production, is significantly influenced by mitochondrial calcium (Ca) levels, which enhance ATP production but must be carefully balanced to prevent cell death.
- The relationship between mitochondrial Ca and oxidative phosphorylation is particularly important in cardiac health and diseases, affecting conditions like heart failure and arrhythmias by regulating energy supply and reactive oxygen species (ROS) responses.
- Targeting mitochondrial Ca could be a promising therapeutic strategy to treat various cardiac diseases linked with energy dysfunction and irregular heart rhythms.
Article Synopsis
- Mitochondrial ion channels help cells produce energy and stay alive, but most of them are very specific and open for short times.
- A new type of channel called LUNA is found all over the body, does not choose which ions to let in, and has a strong current.
- LUNA is more active when the heart is under stress, which might mean it changes from helping the cell to letting more ions in when the cell is in trouble.
Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner mitochondrial membrane (IMM), where it dissipates membrane potential independent of adenosine triphosphate (ATP) synthase. Here, we provide evidence that phosphatidylethanolamine (PE) modulates UCP1-dependent proton conductance across the IMM to modulate thermogenesis.
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