Early Maternal Thyroid Function During Gestation Is Associated With Fetal Growth, Particularly in Male Newborns.

Background: Intrauterine growth patterns are influenced by maternal thyroid function during gestation and by fetal sex. It is unknown, however, whether the relationships between maternal thyrotropin (TSH) and free thyroxine (fT4) levels in early pregnancy and fetal growth outcomes are modified by fetal sex.

Design: Data were obtained from a community-based cohort study of pregnant women living in Amsterdam (Amsterdam Born Children and Their Development study).

Is first trimester vitamin D status in nulliparous women associated with pregnancy related hypertensive disorders?

Objectives: this study aimed to explore if maternal vitamin D status in early pregnancy was associated with pre-eclampsia and pregnancy-induced hypertension. Relationships between vitamin D status and blood pressure at the start of pregnancy as well as the occurrence of a mid-pregnancy drop in blood pressure were also explored. This secondary analysis was completed to investigate a possible mechanism for the association between vitamin D status and pregnancy related hypertensive disorders.

The Association between Maternal 25-Hydroxyvitamin D Concentration during Gestation and Early Childhood Cardio-metabolic Outcomes: Is There Interaction with Pre-Pregnancy BMI?

Both maternal 25-hydroxyvitamin D (25OHD) status and pre-pregnancy BMI (pBMI) may influence offspring cardio-metabolic outcomes. Lower 25OHD concentrations have been observed in women with both low and high pBMIs, but the combined influence of pBMI and 25OHD on offspring cardio-metabolic outcomes is unknown. Therefore, this study investigated the role of pBMI in the association between maternal 25OHD concentration and cardio-metabolic outcomes in 5-6 year old children.

Do neighborhood characteristics in Amsterdam influence adiposity at preschool age?

Background: Neighborhood characteristics may contribute to adiposity in young children, but results in the current literature are inconsistent. This study aimed to investigate whether objective (socioeconomic status (SES)) and subjective (perceived safety, satisfaction with green spaces and perceived physical disorder) neighborhood characteristics directly influence child adiposity (as measured by BMI, percent body fat (%BF) and waist-to-height ratio (WHtR)).

Methods: Data on child BMI, %BF and WHtR were obtained from the Amsterdam Born Children and their Development cohort at 5-6 years of age.

A nose for trouble--the role of off-flavours in assuring safe drinking water.

A detailed review of drinking water disease outbreaks over the past 30 years in 15 affluent countries produced over 70 case studies, some involving fatalities, which revealed a number of common factors in these disasters. Some of these outbreaks involved off-flavours, either as a driver for reducing disinfection and making the system vulnerable to pathogenic contamination or as an early warning of contamination that was not responded to with sufficient urgency or efficiency to avoid a disease outbreak. The characteristics of these outbreaks are recounted and the important link they reveal between aesthetically pleasing drinking water and safety is documented.