Publications by authors named "E Jeffs"
Background: In recessive dystrophic epidermolysis bullosa (RDEB), complications like oesophageal strictures, hand contractures, cardiomyopathy and cutaneous squamous cell carcinoma (SCC) may develop, necessitating procedures such as oesophageal dilatation (OD), gastrostomy tube placement and hand surgery.
Objectives: To determine prevalence and age of onset of milestone events by RDEB subtype, specifically dysphagia, first OD, first gastrostomy tube, first hand surgery, cardiomyopathy, first SCC and death.
Methods: The Prospective Epidermolysis Bullosa Longitudinal Evaluation Study (PEBLES) is a register study of individuals with RDEB which records comprehensive EB- and non-EB-related health information.
Article Synopsis
- A study reviewed medical records from eight hospitals in Australia and New Zealand examining how intravenous aciclovir is prescribed for suspected herpes simplex virus (HSV) disease in neonates and older children between January and December 2019.
- Out of 1,426 patients, most received aciclovir for suspected cases without definitive HSV testing; notably, only a small fraction had confirmed diagnoses among older children, indicating potentially excessive and unjustified prescribing.
- Among the patients, adverse effects included instances of nephrotoxicity and extravasation injuries, raising concerns about the safety and necessity of such treatments in the pediatric population.
Aim: To explore collaboration and social dynamics within paediatric Morbidity and Mortality meetings.
Design: Qualitative Exploratory Case Study Methodology incorporating semi-structured interviews and qualitative observations.
Methods: Data were collected in a large quaternary paediatric hospital in Melbourne, Australia.
Article Synopsis
- Pain is a significant issue for individuals with epidermolysis bullosa (EB), impacting their quality of life and identified as a priority for improved treatments.
- The Prospective EB Longitudinal Evaluation Study (PEBLES) gathered data over eight years from 61 participants to evaluate pain characteristics and treatments in different RDEB subtypes.
- Results showed that 93% of participants experienced pain, with a median background pain score of 40 and procedural pain score of 52; many did not use medication for pain management despite its severity.
Purpose: Early treatment is advised for breast cancer-related arm lymphoedema (BCRL), a common sequelae of breast cancer treatment. Expert guidance recommends two-phase decongestive lymphoedema treatment (DLT), although evidence is lacking for current treatment protocols and UK women are routinely offered self-treatment with hosiery. This systematic review considered evidence regarding treatment of early BCRL, that is, within 12 months of developing BCRL.
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