Publications by authors named "E Janzen"
Introduction: Newborn screening (NBS) programs for a defined set of eligible diseases have been enormously successful, but genomic NBS allowing for detection of additional treatable disorders has not been broadly implemented. All 3 types of primary hyperoxaluria (PH1-3) are rare autosomal recessive diseases caused by distinct defects of glyoxylate metabolism that are diagnosed genetically with certainty. Early diagnosis and treatment are mandatory to avoid renal failure or sequalae associated with persistent hyperoxaluria.
View Article and Find Full Text PDFBound states in the continuum (BICs) garnered significant interest for their potential to create new types of nanophotonic devices. Most prior demonstrations were based on arrays of dielectric resonators, which cannot be miniaturized beyond the diffraction limit, reducing the applicability of BICs for advanced functions. Here, we demonstrate BICs and quasi-BICs based on high-quality factor phonon-polariton resonances in isotopically pure hBN and how these states can be supported by periodic arrays of nanoresonators with sizes much smaller than the wavelength.
View Article and Find Full Text PDFArticle Synopsis
- - Polaritons can confine light at the nanoscale, especially in two-dimensional (2D) materials, making their study essential for advanced applications.
- - Previous methods focused on optical measurements, but this research introduces a way to electrically detect 2D polaritons using a high-quality 2D-material heterostructure as both a polaritonic platform and a photodetector.
- - The study highlights the successful electrical detection of mid-infrared polaritonic nanoresonators, which exhibit extreme confinement and high-quality factors, paving the way for new developments in compact sensing and imaging technologies.
Article Synopsis
- Modern life is homochiral, meaning it primarily utilizes D-sugars in nucleic acids and L-amino acids in proteins, suggesting a significant evolutionary process.
- The concept of a prebiotic RNA World implies that L-amino acids arose due to chiral transfer from an earlier D-RNA World, facilitated by aminoacyl-RNAs that helped develop the genetic code.
- Research using D-ribozymes shows that while there is detectable chiral selectivity favoring certain enantiomers, it does not support the idea that D-RNA inherently prefers to react with L-amino acids, indicating that L-proteins can originate from different chiral contexts.
Article Synopsis
- Topological photonics allows for light control that is resilient against manufacturing flaws, but past experiments have mostly worked at the vacuum wavelength level.* -
- This study demonstrates deep subwavelength topological edge states in a van der Waals heterostructure, achieving confinement in a volume much smaller than the corresponding free-space wavelength.* -
- The findings suggest potential applications in integrating various polaritonic materials, enhancing operational frequency ranges, and aligning with electronic systems.*