Publications by authors named "E J van Someren"

Background: Fragmented rapid eye movement (REM) sleep disrupts the overnight resolution of emotional distress, a process crucial for emotion regulation. Emotion dysregulation, which is common across psychiatric disorders, is often associated with sleep disturbances. This systematic review explores how REM sleep and nightmares affect emotion processing and regulation in individuals with psychiatric disorders where emotion dysregulation is a key concern, suggesting novel sleep-related treatment pathways.

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This article describes the development of a Safe-by-Design (SbD) module and its integration into an easy-to-use tool, named the Nano Exposure Quantifier-Safe-by-Design (NEQ-SbD) tool. The NEQ-SbD tool guides its user to lower the exposure to nanomaterials at the worksite where nanomaterials are manipulated or handled during a wide range of activities. This allows the tool user with an informed decision to assess airborne exposure and to select, compare, and identify appropriate risk management measures (RMM).

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Sleep disturbances and reduced physical activity (PA) are important risk factors for poor physical and mental health outcomes in people with psychosis. However, the precise interrelations between sleep, PA and psychopathology remain unclear. This study combined experience sampling (ESM) and actigraphy in thirty-two patients with a schizophrenia spectrum disorder to investigate interrelations of day-to-day variations in actigraphic estimates of PA and sleep and psychotic and affective symptoms.

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Article Synopsis
  • The study investigates the use of dexmedetomidine, a selective α2 noradrenergic agonist, as a potential treatment for insomnia, especially in patients dealing with heightened distress, through new oro-mucosal delivery methods.
  • Two formulations (sublingual and buccal) were tested in a pilot and main study involving both good and poor sleepers, focusing on pharmacokinetic and pharmacodynamic profiles alongside a range of sleep assessments.
  • Results showed that buccal dexmedetomidine was quickly absorbed and effectively reduced sleep latency and increased NREM sleep duration in poor sleepers, while not significantly affecting cortisol or heart rate levels.
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Hyperarousal is a key symptom of anxiety, stress-related disorders, and insomnia. However, it has been conceptualized in many different ways, ranging from various physiological markers (e.g.

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