Publications by authors named "E J van Erp"
Article Synopsis
- RSV is a significant cause of severe respiratory infections in infants and the elderly, with an important but not fully understood role of the immune response.
- Platelets are recognized as immune cells and may affect viral diseases by releasing chemokines, which can influence immune cell attraction to infections like RSV.
- Research showed that while platelets can bind and internalize RSV particles, they do not undergo degranulation and, therefore, likely do not contribute directly to the inflammation associated with RSV.
Article Synopsis
- RSV (Respiratory syncytial virus) is a leading cause of severe respiratory infections in infants, highlighting the need for better understanding of maternal antibodies and their role in protection.
- Antibody levels alone do not effectively correlate with protection against RSV; instead, the ability of antibodies to activate natural killer (NK) cells may be more critical.
- The study suggests that the quality of antibodies, particularly their Fc-glycosylation status, affects NK cell activation and may play a significant role in protecting against severe RSV disease, indicating potential avenues for vaccine improvement.
Article Synopsis
- Human respiratory syncytial virus (RSV) is a leading cause of severe respiratory illness in infants, with no approved treatments or vaccines currently available.
- The study focuses on comparing different methods of RSV inoculation in mice, specifically looking at intranasal and intratracheal methods.
- Results show that intranasal inoculation leads to greater pathology and inflammation in mice, suggesting it is a better model for studying RSV infection and aiding the development of future therapies.
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections and hospitalization in infants under 1 year of age and there is currently no market-approved vaccine available. For protection against infection, young children mainly depend on their innate immune system and maternal antibodies. Traditionally, antibody-mediated protection against viral infections is thought to be mediated by direct binding of antibodies to viral particles, resulting in virus neutralization.
View Article and Find Full Text PDFNatural killer (NK) cells are essential in the early immune response against viral infections, in particular through clearance of virus-infected cells. In return, viruses have evolved multiple mechanisms to evade NK cell-mediated viral clearance. Several unrelated viruses, including influenza virus, respiratory syncytial virus, and human immunodeficiency virus, can directly interfere with NK cell functioning through infection of these cells.
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