Publications by authors named "E J Wendel"
Background And Objectives: Pediatric patients with acute disseminated encephalomyelitis (ADEM) are at risk of impaired brain growth, with long-term neuropsychiatric consequences. We previously reported transient expansions of cerebral ventricle volume (VV) in experimental autoimmune encephalomyelitis, which subsequently normalized. In this study, we investigated changes in VV in ADEM in relation to other brain structures and clinical outcomes.
View Article and Find Full Text PDFBackground: Fulminant idiopathic intracranial hypertension (IIH) is characterized by headache, rapid decrease of vision and elevated CSF-opening pressure.
Objective: To delineate a subgroup of MOGAD mimicking fulminant IIH.
Methods: In this case series children with MOGAD with vision loss, optic disc swelling and elevated CSF opening pressure, initially diagnosed with fulminant IIH, were included.
Long-term follow-up MR imaging in children with transverse myelitis.
Mult Scler Relat Disord
December 2024
Article Synopsis
- The study investigates how lesions in children with transverse myelitis (TM) resolve over time, focusing on different related diseases: MOG-antibody associated disorders (MOGAD), multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and double seronegative TM.
- A total of 78 children from various medical centers were assessed, and a grading system was used to measure the resolution of lesions over time.
- Results showed that MOGAD had the fastest and most complete resolution of lesions, followed by double seronegative TM, MS, and NMOSD, with none of the NMOSD patients achieving complete resolution during the observation period.
CSF-profile and hypocretin levels in children with narcolepsy type 1 and 2.
Eur J Paediatr Neurol
November 2024
Background: Narcolepsy is a rare neurological disease caused by dysfunction of hypocretin-producing neurons. Hypocretin concentrations in the cerebrospinal fluid (CSF) of less than 110 pg/ml are considered pathological in adults.
Objectives: To compare hypocretin levels of children with narcolepsy type 1, type 2 and disease control groups, in addition to a detailed CSF analysis, clinical and polysomnographic parameters.
Article Synopsis
- The study focuses on comparing blood parameters in children with myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD), AQP4-IgG-positive neuromyelitis optica spectrum disorders (NMOSD), multiple sclerosis (MS), and healthy controls to better understand disease activity.
- Researchers analyzed complete blood counts and various ratios (like NLR and PLR) during different disease phases: clinical attack, acute treatment, and remission across a cohort of 174 children and adolescents.
- Key findings revealed elevated leukocyte counts in MOGAD during clinical attacks, while other blood parameters like NLR and PLR showed different trends, suggesting these measures could aid in assessing disease activity and distinguishing between disease