Predicting conversion to psychosis using machine learning: response to Cannon.

Background: We previously reported that machine learning could be used to predict conversion to psychosis in individuals at clinical high risk (CHR) for psychosis with up to 90% accuracy using the North American Prodrome Longitudinal Study-3 (NAPLS-3) dataset. A definitive test of our predictive model that was trained on the NAPLS-3 data, however, requires further support through implementation in an independent dataset. In this report we tested for model generalization using the previous iteration of NAPLS-3, the NAPLS-2, using the identical machine learning algorithms employed in our previous study.

Cloning a Chloroplast Genome in and .

Chloroplast genomes present an alternative strategy for large-scale engineering of photosynthetic eukaryotes. Prior to our work, the chloroplast genomes of (204 kb) and (140 kb) had been cloned using bacterial and yeast artificial chromosome (BAC/YAC) libraries, respectively. These methods lack design flexibility as they are reliant upon the random capture of genomic fragments during BAC/YAC library creation; additionally, both demonstrated a low efficiency (≤ 10%) for correct assembly of the genome in yeast.

Retinal Vessels Whitening in Retinitis Pigmentosa.

Purpose: To characterize retinal vessel whitening (RVW) in Retinitis Pigmentosa (RP).

Methods: Single-center cross-sectional study. Review of clinical notes of clinically confirmed RP patients was performed followed by grading ultra-widefield imaging.

Effect of condensed heat acclimation on thermophysiological adaptations, hypoxic cross-tolerance, exercise performance and de-acclimation.

Short duration heat acclimation (HA) (≤5 daily heat exposures) elicits incomplete adaptation compared to longer interventions, possibly due to the lower accumulated thermal 'dose'. It is unknown if matching thermal 'dose' over a shorter timescale elicits comparable adaptation to a longer intervention. Using a parallel-groups design, we compared: i) 'condensed' HA (CHA; =17 males) consisting of 4×75 min∙day heat exposures (target rectal temperature ()=38.

Barriers to accessing mental health resources as perceived by surgical compared to medical trainees.

Introduction: Despite myriad wellness programs, training demands restrict resident access. This study aimed to evaluate barriers to accessing mental health resources(MHR) and determine if differences exist between medical(MT) and surgical trainees(ST).

Methods: A cross-sectional survey was performed in one health system assessing awareness of and barriers to accessing MHR.