Publications by authors named "E J Vesely"
Contemporary antifungal therapies utilized to treat filamentous fungal infections are inhibited by intrinsic and emerging drug resistance. Consequently, there is an urgent need to develop novel antifungal compounds that are effective against drug-resistant filamentous fungi. Here, we utilized an cell-based high-throughput screen to identify small molecules with antifungal activity that also potentiated triazole activity.
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- Many patients with cystic fibrosis (PwCF) test positive for harmful fungi, and over 90% are treated with the medication Trikafta.
- Research shows that Trikafta decreases the biomass and viability of fungal biofilms from both lab and clinical strains.
- Trikafta also alters how biofilms react to stress on their cell walls, which could affect how the immune system fights fungal infections.
can cause a life-threatening infection known as invasive pulmonary aspergillosis (IPA), which is marked by fungus-attributable mortality rates of 20%-30%. Individuals at risk for IPA harbor genetic mutations or incur pharmacologic defects that impair myeloid cell numbers and/or function, exemplified by bone marrow transplant recipients, patients that receive corticosteroid therapy, or patients with chronic granulomatous disease (CGD). However, treatments for infections remain limited, and resistance to the few existing drug classes is emerging.
View Article and Find Full Text PDFUnlabelled: Invasive pulmonary aspergillosis (IPA) is a life-threatening infection caused by species in the ubiquitous fungal genus . While leukocyte-generated reactive oxygen species (ROS) are critical for the clearance of fungal conidia from the lung and resistance to IPA, the processes that govern ROS-dependent fungal cell death remain poorly defined. Using a flow cytometric approach that monitors two independent cell death markers, an endogenous histone H2A:mRFP nuclear integrity reporter and Sytox Blue cell impermeable (live/dead) stain, we observed that loss of cytochrome c ( ) results in reduced susceptibility to cell death from hydrogen peroxide (H O ) treatment.
View Article and Find Full Text PDFBackground: Statin intolerance is a key barrier to the effective prevention of atherosclerotic cardiovascular disease (ASCVD). Experts do not agree on what it is and how to respond to this problem clinically.
Objective: To characterize the range of expert recommendations about the care of patients with statin intolerance.