Predictive modeling and interpretative analysis of risks of instability in patients with Myasthenia Gravis requiring intensive care unit admission.

Objective: Myasthenia gravis (MG), a low-prevalence autoimmune disorder characterized by clinical heterogeneity and unpredictable disease fluctuations, presents significant risks of acute exacerbations requiring intensive care. These crises contribute substantially to patient morbidity and mortality. This study aimed to develop and validate machine-learning models for predicting intensive care unit (ICU) admission risk among patients with MG-related disease instability.

Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma.

Purpose: Investigate the influence of baseline blood pressure (BP) on retinal nerve fiber layer (RNFL) rates of change (RoC) in glaucoma patients with central damage or moderate to severe disease.

Design: Prospective cohort study.

Participants: 110 eyes with ≥4 RNFL optical coherence tomography scans and ≥2 years of follow-up.

Dengue virus non-structural protein 1 binding to thrombin as a dengue severity marker: Comprehensive patient analysis in south Taiwan.

Background: Previously we identified a complex of non-structural protein (NS) 1 - Thrombin (NST) in dengue infected patients. Here, we investigated how the concentration of NS1 and NST differ in various dengue severity levels as well as their demographic and clinical features. Several comorbid (hypertension, diabetes, and chronic renal failure) often found in dengue patients were also measured and analyzed.

Photoacoustic and fluorescence dual-modality imaging of cerebral biomarkers in Alzheimer's disease rodent model.

Significance: Alzheimer's disease (AD) is a predominant form of dementia that can lead to a decline in the quality of life and mortality. The understanding of the pathological changes requires monitoring of multiple cerebral biomarkers simultaneously with high resolution. Photoacoustic microscopy resolves single capillaries, allowing investigations into the most affected types of vessels.

BRCA2 germline mutation carrier with five malignancies: a case report.

Background: BRCA2 germline mutations are known to predispose carriers to various cancer types, including breast, ovarian, pancreatic and prostate cancer. An association with melanoma has also been reported. However, the full tumour spectrum associated with BRCA2 mutations, particularly in patients with other concurrent pathogenetic mutations, is unexplored.