Publications by authors named "E J Speel"
Although most patients with pulmonary carcinoid (PC) can be cured by surgery, relapse may occur until 15 years after resection in up to 10% of patients. This is unpredictable at the outset, necessitating extensive follow-up (FU). We sought to determine whether an immunohistochemical marker panel (OTP, CD44, Ki-67) could provide better indication for relapse-free survival (RFS) and increase uniformity among pathologists regarding carcinoid classification.
View Article and Find Full Text PDFIntroduction: Multi-omic studies have identified three molecular separated pulmonary carcinoid (PC) subgroups (A1, A2, B) with distinctive mRNA expression profiles (e.g., orthopedia homeobox protein [OTP], achaete-scute homolog [ASCL1], and hepatocyte nuclear factor 1 homeobox A [HNF1A]).
View Article and Find Full Text PDFArticle Synopsis
- - After surgery for pulmonary carcinoids, the low recurrence rate (around 10%) suggests a need for regular scans, but young patients face risks from radiation, so careful consideration is essential.
- - A study analyzed follow-up guidelines from ENETS and ESMO, evaluating radiation exposure and potential lifetime cancer risks for young patients, particularly focusing on data from the Netherlands Cancer Registry.
- - The findings indicated that young patients generally didn't experience recurrence, suggesting that a more personalized, less intensive follow-up approach could reduce their radiation exposure and associated cancer risks. The study advocates for using predictive biomarkers to tailor follow-up strategies.
Worldwide, the incidence of renal cell carcinoma (RCC) is rising, accounting for approximately 2% of all cancer diagnoses and deaths. The etiology of RCC is still obscure. Here, we assessed the presence of HPyVs in paraffin-embedded tissue (FFPE) resected tissue from patients with RCC by using different molecular techniques.
View Article and Find Full Text PDFHuman papillomavirus (HPV) infections are an increasing cause of oropharyngeal squamous cell carcinomas (OPSCC). Integration of the viral genome into the host genome is suggested to affect carcinogenesis, however, the correlation with OPSCC patient prognosis is still unclear. Research on HPV integration is hampered by current integration detection technologies and their unsuitability for formalin-fixed paraffin-embedded (FFPE) tissues.
View Article and Find Full Text PDF