Publications by authors named "E J Sherman"
T cells respond swiftly, specifically, sensitively, and robustly to cognate antigens presented on the surface of antigen presenting cells. Existing microscopic models capture various aspects of early T-cell antigen receptor (TCR) signaling at the molecular level. However, none of these models account for the totality of the data, impeding our understanding of early T-cell activation.
View Article and Find Full Text PDF: Intravenous fluid shortages have led to fluid-sparing measures such as intravenous push (IVP) administration of antibiotics. This study aimed to compare the safety and efficacy of IVP and intravenous piggyback (IVPB) ceftriaxone in critically ill patients. : Demographics were similar in IVP ( = 201) and IVPB ( = 200) groups.
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- - The study tested regorafenib, a multi-targeted tyrosine kinase inhibitor, for treating patients with recurrent/metastatic adenoid cystic carcinoma (ACC), aiming to evaluate its effectiveness and identify biomarkers related to treatment response.
- - Among 38 patients, no objective responses were observed, but 45% achieved 6-month progression-free survival (PFS), with longer PFS linked to specific immune-related tumor profiles and the presence of NOTCH1 or KDM6A alterations associated with poorer outcomes.
- - The findings suggest that combining CDK4/6 inhibitors with VEGFR-TKIs might improve treatment efficacy, emphasizing the need to consider the role of the immune microenvironment in ACC treatment resistance.