Publications by authors named "E J Shannon"
Renal cell carcinoma (RCC) is characterized by recurrent somatic mutations in epigenetic regulators, which stratify patients into clinically significant subgroups with distinct prognoses and treatment responses. However, the cell type-specific epigenetic landscape of RCC-broadly and in the context of these mutations-is incompletely understood. To investigate these open questions, we integrated single nucleus ATAC sequencing data from RCC tumors across four independent cohorts.
View Article and Find Full Text PDFEsophageal adenocarcinoma (EAC) is a highly lethal cancer of the upper gastrointestinal tract with rising incidence in western populations. To decipher EAC disease progression and therapeutic response, we performed multiomic analyses of a cohort of primary and metastatic EAC tumors, incorporating single-nuclei transcriptomic and chromatin accessibility sequencing, along with spatial profiling. We identified tumor microenvironmental features previously described to associate with therapy response.
View Article and Find Full Text PDFArticle Synopsis
- Sodium bicarbonate (NaHCO) ingestion has shown positive effects on performance during high-intensity exercise, but this study focuses on its impact on longer durations, specifically a 40 km time trial for trained cyclists.
- Fourteen male cyclists ingested NaHCO or a placebo in a controlled experiment, and results indicated that NaHCO not only improved their time by an average of 54 seconds but also enhanced their blood buffering capacity during the trial.
- The findings suggest that using NaHCO mini-tablets delivered in a carbohydrate hydrogel is an effective strategy for cyclists seeking to boost performance while experiencing minimal gastrointestinal discomfort.
Background: Low-density lipoprotein cholesterol (LDL-C) is used to guide lipid-lowering therapy after a myocardial infarction (MI). Lack of LDL-C testing represents a missed opportunity for optimizing therapy and reducing cardiovascular risk.
Objectives: The purpose of this study was to estimate the proportion of Medicare beneficiaries who had their LDL-C measured within 90 days following MI hospital discharge.