Publications by authors named "E J Schofield"
Retinopathy with Vitamin E Deficiency (RVED) is a familial disease in the English Cocker Spaniel (ECS) dog breed. Ophthalmic abnormalities observed in RVED-affected ECS include lipofuscin granule deposition within the tapetal fundus and subsequent retinal degeneration resulting in visual deficits. Affected dogs may also exhibit neurological signs that include ataxia and hindlimb proprioceptive deficit.
View Article and Find Full Text PDFBackground: The World Health Organisation has suggested antenatal education be integrated within standard antenatal care. However, evidence for the impact of antenatal education varies. This systematic review and meta-analysis evaluated randomised controlled trial evidence regarding the influence of antenatal education on labour and birth outcomes.
View Article and Find Full Text PDFArticle Synopsis
- PEG consolidation treatment is a common method for preserving wooden cultural artifacts, but its underlying mechanisms are not fully understood, particularly in relation to interactions with cellulose.
- A combination of molecular dynamics and Monte Carlo simulations, alongside experimental analysis, revealed that PEG200 effectively reduces moisture absorption and swelling in wood, though high concentrations can lead to increased swelling at high humidity.
- The study identifies two primary mechanisms for PEG's consolidation effect: it fills wood porosities to reduce moisture uptake and limits excessive swelling, providing insights for developing improved consolidant materials.
The Blood-Brain Barrier in Both Humans and Rats: A Perspective From 3D Imaging.
Int J Biomed Imaging
August 2024
Article Synopsis
- - The study focuses on imaging the blood-brain barrier (BBB) using advanced techniques in order to better understand its 3D structure in both human and rat brain tissue.
- - Researchers used the CUBIC clearing method along with confocal and two-photon microscopes to visualize and reconstruct the BBB, revealing uneven expression of certain proteins in human brain endothelial cells.
- - Findings indicated that astrocytes only partially cover blood vessels, highlighting significant structural differences between the 3D BBB and previously understood 2D models, and suggesting that tissue clearing and 3D imaging could enhance our understanding of biological structures.