Publications by authors named "E J Ring"
Background: A significant proportion of inflammatory bowel disease (IBD) patients fail to respond to advanced therapies. Combining advanced therapies may improve treatment outcome. This study aimed to assess the effectiveness, adverse events, and costs associated with combining advanced therapies in IBD patients.
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- Recurrent brain tumors are a major cause of cancer-related deaths in children, and the study focused on indoximod, which inhibits a metabolic checkpoint called IDO and may enhance anti-tumor immunity post-chemotherapy.
- A phase I trial was conducted with 81 pediatric patients, using indoximod in combination with temozolomide or radiation, to assess its safety and determine the appropriate dosage.
- Results showed a median overall survival of 13.3 months for recurrent cases, with patients who responded to treatment experiencing significantly longer survival, and the findings indicate potential for further trials to evaluate indoximod's effectiveness in treating pediatric brain tumors.
Aims: Patients with haemochromatosis (HFE) are known to have an increased risk of developing hepatocellular carcinoma (HCC). Available data are conflicting on whether such patients have poorer prognosis, and there is lack of data regarding the biology of HFE-HCC. We compared the course of HFE-HCC with a matched non-HFE-HCC control group and examined tumour characteristics using immunohistochemistry.
View Article and Find Full Text PDFBowelScreen paused activity in March 2020 to prioritise the response to the COVID-19 pandemic. The aim of this study was to examine the impact of this delay. Cases affected by the pause and subsequently completed were compared to the same period in 2019.
View Article and Find Full Text PDFObjective: Endoscopy departments have experienced considerable challenges in the provision of endoscopy services since the start of the COVID-19 pandemic. Several studies have reported a reduction of procedures performed by trainee endoscopists during the pandemic. The aim of this study was to assess the impact on colonoscopy training and quality in an academic centre throughout successive waves of the pandemic.
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