Whole-brain T mapping with radial sampling and retrospective motion correction at 3T.

Purpose: Several barriers prevent the use of whole-brain T mapping in routine use despite increasing interest in this parameter. One of the main barriers is the long scan time resulting in patient discomfort and motion corrupted data. To address this challenge, a method for accurate whole-brain T mapping with a limited acquisition time and motion correction capabilities is investigated.

Accelerated 3D multi-echo spin-echo sequence with a subspace constrained reconstruction for whole mouse brain mapping.

Purpose: To accelerate whole-brain quantitative mapping in preclinical imaging setting.

Methods: A three-dimensional (3D) multi-echo spin echo sequence was highly undersampled with a variable density Poisson distribution to reduce the acquisition time. Advanced iterative reconstruction based on linear subspace constraints was employed to recover high-quality raw images.

[Implementation of screening for cytomegalovirus congenital infection in a French type 3 maternity].

Objectives: Congenital cytomegalovirus (CMV) infection is the most common congenital infection and the leading cause of infectious neurosensorial disability in newborns. We wanted to organize the management of women from the beginning of pregnancy allowing access to antenatal treatment with valaciclovir, recognized since 2020 as limiting materno-fetal transmission. To this end, we set up and evaluated the interest of systematic screening for CMV infection in our maternity.

Rapid whole brain 3D T mapping respiratory-resolved Double-Echo Steady State (DESS) sequence with improved repeatability.

Purpose: To propose a quantitative 3D double-echo steady-state (DESS) sequence that offers rapid and repeatable T mapping of the human brain using different encoding schemes that account for respiratory B variation.

Methods: A retrospective self-gating module was firstly implemented into the standard DESS sequence in order to suppress the respiratory artifact via data binning. A compressed-sensing trajectory (CS-DESS) was then optimized to accelerate the acquisition.

Genetic and Functional Characterization of Congenital HCMV Clinical Strains in Ex Vivo First Trimester Placental Model.

Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, leading to a variety of symptoms in the unborn child that range from asymptomatic to death in utero. Our objective was to better understand the mechanisms of placental infection by HCMV clinical strains, particularly during the first trimester of pregnancy. We thus characterized and compared the replication kinetics of various HCMV clinical strains and laboratory strains by measuring viral loads in an ex vivo model of first trimester villi and decidua, and used NGS and PCA analysis to analyze the genes involved in cell tropism and virulence factors.