Publications by authors named "E J McMahon"
Cancerous tissue is a largely unexplored microbial niche that provides a unique environment for the colonization and growth of specific bacterial communities, and with it, the opportunity to identify novel bacterial species. Here, we report distinct features of a novel species, sp. nov.
View Article and Find Full Text PDFObservations of trash in the deep tropical Atlantic and Caribbean Sea.
Mar Pollut Bull
December 2024
Article Synopsis
- Evidence shows that human-induced waste significantly impacts deep-ocean ecosystems, with debris being found even in remote areas during initial explorations.
- A study in the tropical Atlantic and Caribbean Sea recorded various types of marine debris, including plastic, metal, and glass, at depths ranging from 250 to over 6000 meters, observed using submersibles.
- The discovery of 139 debris items—such as a ladder, clothing, and single-use packaging—highlights the severity of pollution in these deep waters and underscores the importance of understanding its effects on ocean sustainability.
The NLRP3 inflammasome is a key target for drug discovery due to its implication in a range of inflammation-related diseases. In this work, we identify new inhibitors of the NLRP3 inflammasome via a hierarchical virtual screening strategy using molecular similarity, docking and MD simulation. The most potent inhibitors identified from a subsequent biological assay (IC of 1 - 4 μM) feature a sulfonamide group, a motif known to favour NLRP3 inhibition, in conjunction with an indole, benzofuran or tricyclic 6,7-dihydro-5H-indeno[5,6-b]furan ring, yielding novel scaffolds.
View Article and Find Full Text PDFBackground: Resilience mechanisms at the individual, family, and environmental levels may improve health outcomes despite potentially harmful stress exposure partly through the practice of positive health behaviors.
Methods: We performed a secondary analysis of 2016-2021 National Survey of Children's Health data to assess the relationships between three resilience domains - child, family, neighborhood - and six health behaviors using multiple regression models adjusted for the other resilience domain(s) and potential confounders.
Results: Analysis revealed significant associations between each resilience domain and multiple health behaviors in a total weighted analytic sample of 70,156,540 children.