This study aimed to compare the pancreatic volume between beta-thalassemia major (β-TM) and beta-thalassemia intermedia (β-TI) patients and between thalassemia patients and healthy subjects and to determine the predictors of pancreatic volume and its association with glucose metabolism in β-TM and β-TI patients. We considered 145 β-TM patients and 19 β-TI patients enrolled in the E-MIOT project and 20 healthy subjects. The pancreatic volume and pancreatic and hepatic iron levels were quantified by magnetic resonance imaging.
View Article and Find Full Text PDFBladder stones in children are rare, 1-5 % of all urinary tract stones. Historically, open cystolithotomy (OCL) was the standard treatment. New methods such as extracorporeal shock wave cystolithotripsy (ESWCL), percutaneous cystolithotomy (PCL), and transurethral cystolithotripsy (TCL) have been introduced to reduce complications and shorten hospital stays.
View Article and Find Full Text PDFBackground: Sarcopenia and frailty are often overlooked in assessing kidney transplant (KT) candidates with chronic kidney disease (CKD), potentially leading to poor post-transplant outcomes. This study aimed to identify metabolites associated with frailty and sarcopenia in KT candidates from the FRAILMar study.
Methods: Between June 2016 and June 2020, we evaluated frailty and sarcopenia in 173 KT candidates using the Physical Frailty Phenotype and EGWSOP-2 criteria, respectively.
Background: Mast cell activation is an important driver of abdominal pain in irritable bowel syndrome (IBS). While evidence supports the role of IgE-mediated mast cell activation in visceral pain development in IBS, the role of pseudoallergic MRGPRX2-mediated mast cell activation in this process remains unknown.
Objective: We investigated whether MRGPRX2-mediated mast cell activation plays a role in abdominal pain development in patients with IBS.