Antimicrobial activity of triethylammonium chloride-N-substituted N'-cyano-O-(triphenylstannyl)-isourea complexes.

The triethylammonium chloride complexes of N-substituted N'-cyano-O-(triphenylstannyl)isoureas were generally found to be better antifungal and antibacterial agents than the uncomplexed compounds.

Synthesis and antimicrobial activity of triorganotin 5-nitro-2-furoates.

Five triorganotin 5-nitro-2-furoates were synthesized by reacting 5-nitro-2-furoic acid with either the corresponding bis(triorganotin) oxide or the corresponding triorganotin hydroxide. The IR spectrum of each compound was obtained over the 4000--200-cm-1 range, and some of the bands were assigned. One compound, tri-n-butyltin 5-nitro-2-furoate, was an excellent antifungal agent, completely inhibiting the growth of six of ten test fungi at a concentration of 1 microgram/ml.

Antimicrobial activity of N-substituted N-(triphenylstannyl)cyanamides and triethylammonium (organocyanoamino)chlorotriphenylstannates.

N-Substituted N-(triphenylstannyl)cyanamides were studied and found to be better antifungal agents than the previously tested N-substituted N'-cyano-S-(triphenylstannyl)isothioureas and N-substituted N'-cyano-O-(triphenylstannyl)isoureas. They were similar in activity to the previously tested ethyl N-aryl-S-(triphenylstannyl)-isothiocarbamates. The antifungal activity of triethylammonium (organocyanoamino)chlorotriphenylstannates, which are the triethylammonium chloride complexes of N-substituted N-(triphenylstannyl)-cyanamides, was similar to or better than that of the N-substituted N-(triphenylstannyl)cyanamides.

Synthesis and antimicrobial activity of ethyl N-aryl-S-(triphenylstannyl)isothiocarbamates.

Five ethyl N-aryl-S-(triphenylstannyl)isothiocarbamates were synthesized by the reaction of triphenyltin iodide with the appropriate ethyl N-arylthiocarbamate in the presence of triethylamine. The IR spectrum of each compound was obtained over the 4000--200-cm--1 range, and some bands were assigned. These new compounds were found to be generally better antifungal agents than the previously tested N-substituted N'-cyano-S-(triphenylstannyl)isothioureas.

Synthesis and antimicrobial activity of N-substituted N'-cyano-S-(triorganostannyl)isothioureas.

Six N-substituted N'-cyano-S-(trimethylstannyl)isothioureas were synthesized by the reaction of (trimethylstannyl)cyanamide with various organic isothiocyanates. The IR spectrum of each compound was obtained over the 4000-30-cm(-1) range, and some bands were assigned. The six new compounds and five previously synthesized N-substituted N'-cyano-S-(triphenylstannyl)isothioureas were tested for and were found to exhibit antifungal activity.