Publications by authors named "E J Kronenberger"
Article Synopsis
- - The study investigates how different pro-inflammatory signals, like Toll-like receptors (TLRs) and cytokines, change the lipid metabolism and composition in macrophages, which are immune cells.
- - Using advanced mass spectrometry techniques, researchers found that each type of TLR and cytokine creates a unique lipid profile in macrophages, showing that there's a specific response to different inflammatory signals.
- - The findings reveal that altering the lipid makeup of macrophages can affect inflammation and enhance the body's defense against bacterial infections, highlighting potential ways to manipulate lipid composition for improved immune responses.
Article Synopsis
- Plasma membranes in animal cells have a high concentration of cholesterol, which is a target for bacteria that produce cholesterol-dependent cytolysins (CDCs), dangerous toxins that form pores in cell membranes.
- Research shows that interferon (IFN) signals help macrophages and neutrophils resist the harmful effects of CDCs by quickly changing a specific type of cholesterol in their membranes, without affecting overall cholesterol levels.
- This resistance relies on the production of 25-hydroxycholesterol (25HC), blocking cholesterol synthesis, and redistributing cholesterol into an esterified form; disrupting this process makes cells more vulnerable to CDC damage.
