Flexible neural population dynamics govern the speed and stability of sensory encoding in mouse visual cortex.

Time courses of neural responses underlie real-time sensory processing and perception. How these temporal dynamics change may be fundamental to how sensory systems adapt to different perceptual demands. By simultaneously recording from hundreds of neurons in mouse primary visual cortex, we examined neural population responses to visual stimuli at sub-second timescales, during different behavioural states.

Walking humans and running mice: perception and neural encoding of optic flow during self-motion.

Locomotion produces full-field optic flow that often dominates the visual motion inputs to an observer. The perception of optic flow is in turn important for animals to guide their heading and interact with moving objects. Understanding how locomotion influences optic flow processing and perception is therefore essential to understand how animals successfully interact with their environment.

Creating and controlling visual environments using BonVision.

Real-time rendering of closed-loop visual environments is important for next-generation understanding of brain function and behaviour, but is often prohibitively difficult for non-experts to implement and is limited to few laboratories worldwide. We developed BonVision as an easy-to-use open-source software for the display of virtual or augmented reality, as well as standard visual stimuli. BonVision has been tested on humans and mice, and is capable of supporting new experimental designs in other animal models of vision.

Surgery for constipation: systematic review and clinical guidance: Paper 1: Introduction & Methods.

Aim: This manuscript provides the introduction and detailed methodology used in subsequent reviews to assess the outcomes of surgical interventions with the primary intent of treating chronic constipation in adults and to develop recommendations for practice.

Method: PRISMA guidance was adhered to throughout. A literature search was performed in public databases between January 1960 and February 2016.

Surgery for constipation: systematic review and practice recommendations: Results IV: Recto-vaginal reinforcement procedures.

Aim: To assess the outcomes of recto-vaginal reinforcement procedures in adults with chronic constipation.

Method: Standardised methods and reporting of benefits and harms were used for all CapaCiTY reviews that closely adhered to PRISMA 2016 guidance. Main conclusions were presented as summary evidence statements with a summative Oxford Centre for Evidence-Based Medicine (2009) level.