Publications by authors named "E J Gudgin"
Article Synopsis
- Diagnosis of essential thrombocythaemia (ET) is difficult for patients without specific genetic mutations, prompting a study of 320 'triple-negative thrombocytosis' patients to evaluate bone marrow histology and a myeloid gene panel.
- Histology showed that 36.8% of patients had supportive findings indicating myeloproliferative neoplasm, correlating with higher platelet counts, while only 14.6% of gene tests revealed significant variants.
- The study emphasizes the importance of histology in diagnosing 'triple-negative' ET, highlighting the need for caution when relying on myeloid gene panel results and suggesting the development of specific guidelines for such cases.
Article Synopsis
- Many hematological diseases, like myelodysplastic syndromes (MDS), show changes in blood cell abundance and structure, requiring expert analysis for accurate diagnosis.
- Haemorasis is a computational method that analyzes blood slides, detecting and characterizing white and red blood cells in patients with various conditions, including different types of MDS and anemia.
- The study shows that Haemorasis can effectively distinguish between SF3B1-mutant MDS and other conditions using machine learning, highlighting its potential for improving routine diagnostic processes.
Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 has recently been identified as a critical tumour checkpoint, augmenting the expression and function of programmed death-ligand 1. We raised a monoclonal antibody, A9E8, specific for Siglec-15 using phage display. A9E8 stained myeloid leukaemia cell lines and peripheral cluster of differentiation (CD)33 blasts and CD34 leukaemia stem cells from patients with acute myeloid leukaemia (AML).
View Article and Find Full Text PDFArgatroban to achieve therapeutic anticoagulation in two patients with acute thrombosis and heparin resistance.
Blood Coagul Fibrinolysis
December 2019
Article Synopsis
- * The first case involved a woman with abdominal arterial thrombosis who developed pulmonary embolism despite treatment with low molecular weight heparin, confirming heparin resistance.
- * The second patient had thrombosis due to sepsis and could not achieve proper anticoagulation with unfractionated heparin; both benefited from argatroban, highlighting its potential in cases of heparin resistance.