Tissierella Bacteremia in the Setting of Polymicrobial Osteomyelitis.

We present a case of bacteremia in the setting of polymicrobial osteomyelitis. is a Gram-variable bacterium that has been rarely documented as the etiologic organism in human infections such as septic arthritis or otitis media, and even more rarely reported as an organism associated with bacteremia. The patient presented with septic shock and the physical exam was notable for gangrene of bilateral feet.

Interventions to address empathy-based stress in mental health workers: A scoping review and research agenda.

Consistently engaging with client distress can negatively impact mental health workers (MHWs). This has been described by the concept of empathy-based stress (EBS) (which encompasses burnout; secondary traumatic stress; compassion fatigue and vicarious trauma). Previous reviews of interventions to reduce EBS have not addressed MHWs as a distinct group, despite evidence suggesting they are particularly vulnerable to it.

Cis-regulatory elements driving motor neuron-selective viral payload expression within the mammalian spinal cord.

Spinal motor neuron (MN) dysfunction is the cause of a number of clinically significant movement disorders. Despite the recent approval of gene therapeutics targeting these MN-related disorders, there are no viral delivery mechanisms that achieve MN-restricted transgene expression. In this study, chromatin accessibility profiling of genetically defined mouse MNs was used to identify candidate cis-regulatory elements (CREs) capable of driving MN-selective gene expression.

Quality of life, religion/spirituality, and dementia risk among Black people in the US.

Objectives: Black people in the United States (US) experience an increased risk of being diagnosed with Alzheimer's disease and related dementias (ADRD). More research is needed on psychosocial factors that may contribute to racial disparities in rates of ADRD. Past work has identified a relationship between quality of life (QoL) and ADRD risk and also found that religion/spirituality (R/S) participation protects against ADRD.

Early degenerative changes are different between partial and complete anterior cruciate ligament injury and associate with joint instability in a skeletally immature porcine model.

Objective: Anterior cruciate ligament (ACL) injuries are a major problem in the pediatric and adolescent populations. Some of these injuries are only partial; yet, there is limited data to inform clinical treatment of such partial tears. It is unknown how injury partial injury impacts long-term degenerative changes in the joint relative to complete injury.