Publications by authors named "E J Giltay"
Background: Motor activity fluctuations in healthy adults exhibit fractal patterns characterized by consistent temporal correlations across wide-ranging time scales. However, these patterns are disrupted by aging and psychiatric conditions. This study aims to investigate how fractal patterns vary across the sleep-wake cycle, differ based on individuals' recency of depression diagnosis, and change before and after a depressive episode.
View Article and Find Full Text PDFIntroduction: Inflammatory and metabolic processes are linked to depression, but only 25-30% of depressed patients show low-grade inflammation and metabolic dysregulation associated with atypical, energy-related symptoms (AES). Interventions targeting immuno-metabolic dysregulation could benefit depressed patients, but currently no consensus exists how to best select patients with immuno-metabolic dysregulations. Therefore, we investigated which combinations of circulating C-reactive protein (CRP) and AES could identify those depressed individuals with significant immuno-metabolic dysregulation.
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- Adverse childhood experiences (ACEs) are linked to long-term mental health issues like PTSD, and are notably more common in military personnel who must preserve mental health for their duties.
- A study with 752 recruits from the Japan Air Self-Defense Force found that self-compassion, which involves treating oneself kindly, significantly reduces PTSD symptoms and is negatively impacted by ACEs.
- The research indicated that self-compassion only partially mediates the relationship between ACEs and PTSD symptoms, suggesting the need for further studies to develop educational programs aimed at increasing self-compassion in individuals with ACEs to help lessen PTSD symptoms.
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- A study examined the emotional and skin-related symptoms in five patients with cutaneous T-cell lymphoma undergoing glucocorticoid treatment, finding that emotional disturbances often accompany this therapy.
- Results showed that as treatment progressed, positive emotions declined, leading to increased irritation and itchy skin the following day.
- The findings suggest that reduced positive emotions at the end of glucocorticoid treatment may be linked to lower energy and motivation, potentially worsening skin-related issues.
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- Depression is typically viewed as a disease caused by a common factor, but this study takes a network approach, focusing on how individual symptoms influence each other and their dynamics over time.
- Using the Symptom Questionnaire-48 (SQ-48), researchers examined patient data with dynamic time warp analyses, discovering significant interconnections between various symptoms and how certain symptoms led to changes in others.
- The study identified five symptoms ('hopeless', 'restless', 'down/depressed', 'feeling tense', and 'no enjoyment') that could be targeted for more effective, personalized treatments, though the focus on severely depressed inpatients limits the generalizability of the findings.