Publications by authors named "E J Gault"
Lancet Infect Dis
October 2024
Article Synopsis
- A study conducted in France during the 2023-24 RSV season analyzed the effectiveness of nirsevimab, a monoclonal antibody, in preventing RSV infections in infants, focusing on breakthrough cases.
- Out of 695 RSV-infected infants, researchers sequenced the full-length RSV genome of 545 infants, identifying that 48% had breakthrough infections despite receiving nirsevimab.
- While no resistance was found in RSV-A infections from nirsevimab-treated infants, two cases of RSV-B showed substitutions linked to resistance, indicating a potential concern for the antibody's effectiveness against this variant.
Am J Transplant
November 2024
Article Synopsis
- Invasive aspergillosis (IA) is a serious and often fatal condition found in liver transplant recipients, with a 37% mortality rate over 12 weeks.
- A study involving 62 IA cases and 124 controls identified key risk factors such as systemic antibiotic use and history of pneumonia that contribute to IA occurrence.
- Factors like Aspergillus colonization and ICU stays significantly increased the risk of mortality among IA cases, while recent use of tacrolimus was found to be protective.
Ann Intensive Care
April 2024
Article Synopsis
- This study investigates COVID-19-associated pulmonary aspergillosis (CAPA) among critically ill patients during the Omicron variant wave, finding it affects 5.1% of patients and 9.1% of those on invasive mechanical ventilation.
- CAPA patients showed higher rates of immunosuppression and required more intensive care measures, like vasopressors and renal therapy, compared to non-CAPA patients.
- While CAPA did not significantly impact day-28 mortality, it was linked to longer mechanical ventilation and ICU stays, suggesting a shift in outcomes with emerging SARS-CoV-2 variants.
Intensive Care Med Exp
August 2023
Article Synopsis
- A study was conducted on 158 adult patients with acute respiratory failure due to SARS-CoV-2, focusing on the impact of various Omicron sublineages, including BA.2, BA.4/BA.5, and BQ.1.1.
- Patients infected with the recent BQ.1.1 variant displayed a higher rate of obesity and a lower rate of immunosuppression compared to those with earlier sublineages.
- Despite these differences in patient characteristics, there was no significant variation in disease severity at ICU admission, organ support needs, or 28-day mortality across the different sublineage groups.
