Ultrasensitive detection of intact SARS-CoV-2 particles in complex biofluids using microfluidic affinity capture.

Measuring virus in biofluids is complicated by confounding biomolecules coisolated with viral nucleic acids. To address this, we developed an affinity-based microfluidic device for specific capture of intact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our approach used an engineered angiotensin-converting enzyme 2 to capture intact virus from plasma and other complex biofluids.

Unburied polytetrafluoroethylene scleral suture erosions and failure of pericardial graft revision.

Purpose: The purpose of this case series is to report three cases of exposed, unburied polytetrafluoroethylene (Gore-tex) sutures used for scleral fixated intraocular lenses and their management, including failure of pericardial patch and success of irradiated corneal patch. This series aims to inform management options for this uncommon adverse event.

Observations: A retrospective case series was conducted of three patients who presented at a tertiary care center with exposure of unburied Gore-tex sutures used for fixation of intraocular lens.

Dysphagia in progressive supranuclear palsy: A scoping review.

Introduction: One of the most prevalent types of atypical parkinsonian syndrome is progressive supranuclear palsy (PSP). PSP is associated with early onset of dysphagia which can result in malnutrition, dehydration, and aspiration pneumonia, affecting quality of life and increasing mortality rate. To date, research describing dysphagia in PSP and its impact is scant.

Evaluation of Educational Activity with Guatemalan Birth Attendants About Helping Babies Breathe.

Guatemala's Infant Mortality Rate was 20th highest in the world at 18 deaths per 1,000 live births in 2022. Part of the problem is lay midwives (LMs) who attend most births at home lack training in helping babies breathe (HBB). LMs transfer babies struggling to breathe to firefighters (FF).

Implementation and Evaluation of a Pediatric Palliative Care Curriculum for Adult-Track HPM Fellows.

Introduction: Hospice and Palliative Medicine (HPM) fellowship training provides education on caring for patients from early childhood through adulthood. Yet, there are few guidelines about how to teach these key components, and more specifically the components of Pediatric Palliative Care (PPC), to fellows who have a variety of backgrounds prior to entering HPM fellowship.

Methods: We created a curriculum in PPC that could be used with adult-track HPM fellows.