Publications by authors named "E J Fleming"
Gut dysbiosis is linked to mortality and the development of graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT), but the impact of cutaneous dysbiosis remains unexplored. We performed a pilot observational study and obtained retroauricular and forearm skin swabs from 12 adult patients prior to conditioning chemotherapy/radiation, and at 1-week, 1-month and 3-months after allogeneic HSCT, and performed shotgun metagenomic sequencing. The cutaneous microbiome among HSCT patients was enriched for gram-negative bacteria such as E coli and Pseudomonas, fungi, and viruses.
View Article and Find Full Text PDFAdvancing Dentistry Through Respectful Inclusion: A Focus on Racial Inequities.
Dent Clin North Am
January 2025
Dentistry has faced, and continues to face, challenges in expanding its ranks to include diverse, especially minoritized, people. American Indian/Alaska Native, Hispanic, and Black representation, for example, has not grown significantly in dentistry. Although dental schools have an accreditation standard to be humanistic environments, it is not clear that dental schools have climates that are functionally inclusive of minoritized people-whether for patients, the student body, staff members, faculty members or leadership.
View Article and Find Full Text PDFObjectives: Part 1 of the RUBY trial (NCT03981796) demonstrated improved survival in patients with primary advanced or recurrent endometrial cancer (EC) treated with dostarlimab plus carboplatin-paclitaxel versus placebo plus carboplatin-paclitaxel. Here, we examine additional efficacy and safety data from patients with mismatch repair deficient/microsatellite instability-high (dMMR/MSI-H) EC in the RUBY trial.
Methods: Patients were randomized 1:1 to dostarlimab 500 mg or placebo plus carboplatin-paclitaxel every 3 weeks for 6 cycles followed by dostarlimab or placebo every 6 weeks for up to 3 years.
Article Synopsis
- * Analyzed data indicated that areas with higher social vulnerability experienced significantly more emergency dental visits and inpatient stays compared to less vulnerable areas, highlighting a correlation between social challenges and dental health issues.
- * Increased availability of dental providers was linked to fewer emergency visits, suggesting that improving access to dental care could alleviate the pressure on emergency services in vulnerable communities.
Article Synopsis
- The text discusses a specific gene, bhlhe22, which plays a crucial role in retinal and brain development by encoding a transcription factor involved in neural differentiation.
- Researchers identified eleven individuals from nine families with variants in this gene linked to a neurodevelopmental disorder characterized by speech limitations, severe motor impairments, intellectual disabilities, and other neurological symptoms, including agenesis of the corpus callosum.
- Genetic analysis revealed that some individuals had harmful missense variants in a critical region of the gene, while others had a recurring frameshift mutation, suggesting that these genetic changes lead to severe cognitive and motor deficits associated with this newly recognized disorder.