Publications by authors named "E J Chambers"
Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable, with typical therapeutic strategies targeting genes or enzymes being ineffective in this domain. In this report, we demonstrate that an antibody targeting the isoDGR damage motif in lung tissue can guide immune clearance of harmful damaged proteins in vivo, effectively reducing age-linked lung inflammation.
View Article and Find Full Text PDFPrevious research has demonstrated that social determinants of health are drivers of medical utilization, cost, and health outcomes. In this study, we compared the mean annual total cost to deliver health services per patient by health-related social need (HRSN) status and total HRSNs using linear regression and ANOVA, respectively. Patients with ≥1 HRSN (n = 8409) yielded $1772 higher annual costs compared to patients without HRSNs (n = 34 775) (P < .
View Article and Find Full Text PDFArticle Synopsis
- Natural killer (NK) cells play a crucial role in managing both viral infections and immune responses during kidney transplants in children, as shown in a study using data from the CTOTC project.
- The study analyzed NK cell phenotypes in 98 pediatric kidney transplant patients and found specific NK cell traits linked to either viral infections or alloimmune events, such as acute rejection.
- These findings suggest that understanding NK cell profiles could help distinguish between risk factors for infections versus those for immune responses after transplantation.
Article Synopsis
- The study investigates how different types of senescent cells in the skin contribute to the development of cancer in patients with Familial Melanoma Syndrome (FMS), who have defects in the CDKN2A gene.
- Melanocytes from FMS patients show lower p16 levels and higher DNA damage markers compared to fibroblasts, while patient fibroblasts also exhibit unusual behaviors, such as increased replicative capacity and defective senescence.
- The findings suggest that the combination of DNA damage in melanocytes and impaired senescence in fibroblasts may weaken the immune response and enhance the risk of melanoma in these patients.
Background And Aims: Physiological shear stress promotes vascular homeostasis by inducing protective molecules in endothelial cells (EC). However, physiological shear stress has been linked to atherosclerosis progression in some individuals with heightened cardiovascular risk. To address this apparent paradox, we hypothesized that diseased arteries may exhibit reduced responsiveness to the protective effects of physiological shear stress.
View Article and Find Full Text PDF