Publications by authors named "E Iu Zykov"
Purpose This research work evaluates monotherapy with checkpoint inhibitors (CPI). as a neoadjuvant treatment for patients with Microsatellite Instability-High (MSI-H) locally advanced gastric cancer. Methods Here we present the results of the retrospective study from Napalkov Cancer Center over 4.
View Article and Find Full Text PDFArticle Synopsis
- A breast cancer patient with estrogen receptor-positive cancer relapsed after two and a half years of treatment, leading to the addition of everolimus to her ongoing exemestane therapy due to the tumor's potential sensitivity to hormone treatment.
- After a brief period on oral chemotherapy failed due to her rapidly worsening health, a BRCA test showed a significant deletion in the BRCA2 gene, prompting the use of olaparib as a last-resort treatment.
- Remarkably, the patient experienced a dramatic recovery known as the "Lazarus response," with her metastatic cancer showing complete metabolic response on a PET-CT scan after just one month of olaparib therapy, highlighting the need for further studies of PARP inhibitors in patients
Objective: To comparatively study the diagnostic capabilities of positron emission tomography (PET) with various tumorotropic radiopharmaceuticals (TRPs) in detecting malignant brain gliomas (BG) and estimating their degree.
Material And Methods: One hundred and fourteen patients, including 47 with histologically verified glioblastoma multiforme (GBM), 27 with anaplastic astrocytoma (AA), 23 with benign astrocytoma (BA), and 17 with postoperative cysts, were examined. PET was performed using TRPs: 18F-fluorodesoxyglucose (18F-FDG), 11C-sodium butyrate (11C-SB), 11C-L-methionine (11C-MET), and 11C-choline (11C-COL).
Examination including MRI (CT), PET with sodium 11C-butyrate (11C-SB) and 18fluorodeoxyglucose (18F-FDG) was carried out in 59 patients with continuing growth of malignant glioma. It was established that 11C-SB-PET is characterized by high sensitivity (94.1%) in detecting continuing growth as well as to differentiating it from necrosis.
View Article and Find Full Text PDF