[Investigation of general toxic effects of Relatox in comparison with Dysport].

Objective: To evaluate the toxic effects of the agent Relatox on mature outbred rats and mice in an acute experiment in comparison with the registered analogue Dysport.

Material And Methods: Based on the aim of experiment, the acute toxic effects of Relatox and Dysport were assessed on two animal species: rats and mice at intraperitoneal and intramuscular administration at dose levels that made it possible to calculate the toxicological parameter values (initially 10-150 U/kg with subsequent usage of additional doses 20 U/kg to 300 U/kg depending on the agent and route of administration). The LD values and other acute toxic parameters were calculated using probit analysis.

Sweet-Tasting Natural Proteins Brazzein and Monellin: Safe Sugar Substitutes for the Food Industry.

This article presents the results of a comprehensive toxicity assessment of brazzein and monellin, yeast-produced recombinant sweet-tasting proteins. Excessive sugar consumption is one of the leading dietary and nutritional problems in the world, resulting in health complications such as obesity, high blood pressure, and cardiovascular disease. Although artificial small-molecule sweeteners widely replace sugar in food, their safety and long-term health effects remain debatable.

[New trends in the epidemic situation of extrathoracic tuberculosis in Siberia and the Far East].

The statistical reports by 21 subjects of the Russian Federation (the Siberian and Far-Eastern Federal Districts) have been analyzed to define the rates of extrathoracic tuberculosis morbidity in these regions and its structure. It has been established that new trends have been recently evident in the pattern of extrathoraric tuberculosis. Firstly, there has been an increase in the incidence of bone and joint tuberculosis, young men and old women being predominant in its structure.