CMF608-a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells.

Microarray gene expression analysis was utilized to identify genes upregulated in primary rat calvaria cultures in response to mechanical force. One of the identified genes designated CMF608 appeared to be novel. The corresponding full-length cDNA was cloned and characterized in more details.

[Determination of unique peptide fragments in nerve growth factors].

A new classificational method based on the availability of peptide fragments unique for a certain protein family is presented. Seven common peptide fragments unique for the nerve growth factor amino acid sequence are determined, and two of them are found in the neurotrophic factor from pig brain.

[Computer analysis and comparison of neurotoxin structures from snake and the anemone Radianthus macrodactylus].

Evolutionary trees of proteins analysed by means of computer comparative methods were reconstructed and the level of the structure and functional relationship was revealed. The distance between the percent amino acid contents was used to classify a group of toxins from the sea anemone Radianthus macrodactylus, which proved to belong to long neurotoxins. The scores were calculated by the pattern recognition method.