Evaluation of health hazards in children from regions with nitrate pollution.

Nitrate pollution of drinking water can be potentially hazardous with health risks for considerable groups of people. Methemoglobin in blood and concentration of nitrates and nitrites in morning saliva, urine, and plasma as sensitive indicators of nitrate accumulation in the body were analysed in 12-14-year-old children living in villages with nitrate pollution of the drinking water. The children were distributed in two experimental groups of 18-21 children each.

Minor Alkaloids of Corydalis bulbosa, Structure of Bulbodione.

As a result of the reinvestigation of the alkaloid content of CORYDALIS BULBOSA (L.) DC. (Papaveraceae), growing in Bulgaria, a new 8,11-dioxoaporphine alkaloid, named bulbodione, together with dihydrosanguinarine, dehydroglaucine, (+/-)-sinactine, glaucinone and bicucullinine were isolated.

Alkaloids of Corydalis slivenensis.

The known alkaloids (-)-stylopine, (-)-canadine, (+/-)-sinactine, (+)-nantenine, (+)-bulbocapnine, protopine, (-)-isocorydine, (-)-domesticine, alpha-allocryptopine and berberine were found in a mixture of alkaloids from Corydalis slivenensis (Papaveraceae), growing in Bulgaria. Dehydronantenine, corydine, predicentrine and isoboldine were detected by means of a thin-layer chromatography. Two other alkaloids - (+)-tetrahydrocorysamine and (-)-cavidine, were identified on the basis of their spectral data.

Alkaloids from Corydalis bulbosa.

A new 4,5-dioxoaporphine, named corydione, was isolated from the whole herb of Corydalis bulbosa (L.) Dc (Papaveraceae), together with dehydronantenine, (-)-stylopine, (+)-bicuculline, (-)-adlumidine, (+)-nantenine, (+)-bulbocapnine, protopine (-)-domesticine, (+)-corydine, predicentrine, oxonantenine, (+)-isoboldine and nandazurine. Glaucine and thaliporphine were detected by means of thin-layer chromatography.