Publications by authors named "E Ishida"
Programs allowing access to investigational drugs and off-label drug use for serious diseases have often been applied to pediatric cancers. A clinical study conducted under the Japanese "Patient-Proposed Healthcare Services" evaluated the efficacy and safety of dabrafenib plus trametinib in children with BRAF V600 mutant glioma (jRCTs071210071). This study successfully provided unapproved and off-label medications to four enrolled patients, two with low-grade glioma and two with high-grade glioma (median age: 10.
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- Osteoporosis leads to increased hip fractures, negatively impacting quality of life, while the connection between tooth loss and bone health is still not fully understood.
- This study examines the effects of tooth loss on memory function and femoral bone mineral density in young male mice, using cognitive tests and imaging analysis over two months.
- Results indicate that tooth loss decreases cognitive function, reduces bone density in the femur and mandible, and lowers levels of a key protein linked to brain health.
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- - Dermatofibrosarcoma protuberans (DFSP) is a type of tumor with varying malignancy levels and is known for high rates of local recurrence; the sclerosing variant is a rare form.
- - A case study of a 77-year-old man with a 2-cm nodule on his chest was complicated by initial biopsy results that resembled sclerotic fibroma, leading to diagnostic confusion.
- - Further examination after an excisional biopsy revealed the tumor contained distinct histopathological regions, displaying features of classic DFSP, sclerotic fibroma-like tissue, and giant cell fibroblastoma-like tissue, emphasizing the need for thorough evaluation in such cases.
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- * A total of 12,036 visitations occurred at SACHICO, including 3,100 initial medical examinations, with a concerningly low reporting rate of 31.3% for these cases; victims under 19 years made up 60% of the initial medical exams.
- * The findings indicate that support for sexual assault victims in Japan remains inadequate, highlighting the need for an improved system of rape crisis centers to provide comprehensive support for victims
The escalating prevalence of diabetes mellitus underscores the need for a comprehensive understanding of pancreatic beta cell function. Interest in glucose effectiveness has prompted the exploration of novel regulatory factors. The myeloid/lymphoid or mixed-lineage leukaemia gene () is widely recognised for its role in leukemogenesis and nuclear regulatory mechanisms through its histone methyltransferase activity in active chromatin.
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