Probing Parton Saturation and the Gluon Dipole via Diffractive Jet Production at the Electron-Ion Collider.

We demonstrate that hard dijet production via coherent inelastic diffraction is a promising channel for probing gluon saturation at the Electron-Ion Collider. By inelastic diffraction, we mean a process in which the two hard jets-a quark-antiquark pair generated by the decay of the virtual photon-are accompanied by a softer gluon jet, emitted by the quark or the antiquark. This process can be described as the elastic scattering of an effective gluon-gluon dipole.

Development of an optimized closed and semi-automatic protocol for Good Manufacturing Practice manufacturing of tumor-infiltrating lymphocytes in a hospital environment.

Background Aims: Several studies report on Good Manufacturing Process (GMP)-compliant manufacturing protocols for the ex vivo expansion of tumor-infiltrating lymphocytes (TILs) for the treatment of patients with refractory melanoma and other solid malignancies. Further opportunities for improvements in terms of ergonomy and operating time have been identified.

Methods: To enable GMP-compliant TILs production for adoptive cell therapy needs, a simple automated and reproducible protocol for TILs manufacturing with the use of a closed system was developed and implemented at the authors' institution.

Challenges and advantages of cell therapy manufacturing under Good Manufacturing Practices within the hospital setting.

Academic medicine serves to advance the scientific field and provide the highest quality of clinical care. This applies to cancer where there is a continuous unmet need for innovation. In the last decade, we have observed a significant development of commercial cell and gene-therapy products with a rapid growth of the industry.

A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian serous carcinoma.

Background: Most ovarian cancer patients are diagnosed at a late stage with 85% of them relapsing after surgery and standard chemotherapy; for this reason, new treatments are urgently needed. Ovarian cancer has become a candidate for immunotherapy by reason of their expression of shared tumor-associated antigens (TAAs) and private mutated neoantigens (NeoAgs) and the recognition of the tumor by the immune system. Additionally, the presence of intraepithelial tumor infiltrating lymphocytes (TILs) is associated with improved progression-free and overall survival of patients with ovarian cancer.

Vacuumlike Jet Fragmentation in a Dense QCD Medium.

We study the fragmentation of a jet propagating in a dense quark-gluon plasma. Using a leading, double-logarithmic approximation in perturbative QCD, we compute for the first time the effects of the medium on multiple vacuumlike emissions. We show that, due to the scatterings off the plasma, the in-medium parton showers differ from the vacuum ones in two crucial aspects: their phase-space is reduced and the first emission outside the medium can violate angular ordering.