Publications by authors named "E Ia Parnes"
10% of patients with acute ST-elevation myocardial infarction (STEMI) treated with reperfusion therapy fail to develop an enzyme rise, but do exhibit transient ECG changes, which are consistent with an aborted myocardial infarction. Following reperfusion by primary PCI in STEMI, oxidative stress and an inflammatory response are induced immediately. Inflammation is a critical component of STEMI.
View Article and Find Full Text PDFActivation of inflammation and enzyme cyclooxygenase with formation of proinflammatory prostaglandins is a key element of development of myocardial infarction in patients with acute coronary syndrome. Basing on literature data and own experience we suggested that single intravenous injection of 230 mg/kg of nonselective inhibitor of type 1 and 2 cyclooxygenase lornaxicam in the phase of initialization of inflammation 20 min after onset of ischemia would lead to reduction of myocardial infarction volume in rats in irreversible ischemia and ischemia with subsequent reperfusion. The conducted study allowed to reveal that administration of lornoxicam in recommended for human use dose lowered mortality of animals and increased number of capillaries per one cardiomyocyte in case of irreversible coronary artery occlusion.
View Article and Find Full Text PDFAim: The study of outcomes of rheumatoid arthritis (RA) depending on cardiac rhythm variability (CRV).
Material And Methods: A total of 78 patients with RA of I--III degree of activity aged 38-83 years (mean age 60.3 +/- 10.
Aim: To characterize a reduction in heart rhythm variability (HRV) in patients with coronary heart disease (CHD), essential hypertension (EH) and in healthy controls during bicycle exercise test (BET).
Material And Methods: BET was made in 21 CHD patients, 23 EH patients and 22 healthy controls (mean age 47.8 years, standard deviation 14 years).