Publications by authors named "E Ia Migunova"
Optical coherence microscopy (OCM) imaging of the (fruit fly) heart tube has enabled the non-invasive characterization of fly heart physiology . OCM generates large volumes of data, making it necessary to automate image analysis. Deep-learning-based neural network models have been developed to improve the efficiency of fly heart image segmentation.
View Article and Find Full Text PDFCardiomyopathy (CM) is a group of diseases distinguished by morphological and functional abnormalities in the myocardium. It is etiologically heterogeneous and may develop via cell autonomous and/or non-autonomous mechanisms. One of the most severe forms of CM has been linked to the deficiency of the ubiquitously expressed RNase Z endoribonuclease.
View Article and Find Full Text PDFAim: To evaluate dynamic changes in the lungs, hemostasis system, immune system in different terms after coronavirus pneumonia.
Materials And Methods: Ventilation-perfusion single-photon emission computed tomography/computed tomography (CT), functional methods of lung investigation, evaluation of hemostasis system, immune status and specific humoral immune response were performed and evaluated in different terms after coronavirus pneumonia. A total of 71 patients were examined according to this protocol.
Article Synopsis
- A severe form of infantile cardiomyopathy (CM) has been linked to mutations in the ELAC2 gene, which is crucial for producing mature tRNAs.
- Researchers used Drosophila melanogaster (fruit flies) with ELAC2's equivalent gene, RNaseZ, to study these mutations and their effects.
- The study found that CM-linked mutations in RNaseZ caused heart issues in the flies similar to those seen in human patients, providing important evidence about how these mutations lead to the disease.