Publications by authors named "E I Verhoef"
Early-life musical engagement is an understudied but developmentally important and heritable precursor of later (social) communication and language abilities. This study aims to uncover the aetiological mechanisms linking musical to communication abilities. We derived polygenic scores (PGS) for self-reported beat synchronisation abilities (PGS) in children (N≤6,737) from the Avon Longitudinal Study of Parents and Children and tested their association with preschool musical (0.
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- There is increasing awareness that signs of autism can emerge beyond the first three years of life, raising questions about the impact of age at diagnosis on developmental trajectories.
- Research using data from four birth cohorts reveals two distinct socio-emotional behavior patterns linked to the age when autism is diagnosed.
- The study also finds that the age at diagnosis has a heritable component and is related to genetic factors, suggesting a complex relationship between autism, the timing of diagnosis, and co-occurring conditions like ADHD and mental health issues.
Common genetic variation has been associated with multiple phenotypic features in Autism Spectrum Disorder (ASD). However, our knowledge of shared genetic factor structures contributing to this highly heterogeneous phenotypic spectrum is limited. Here, we developed and implemented a structural equation modelling framework to directly model genomic covariance across core and non-core ASD phenotypes, studying autistic individuals of European descent with a case-only design.
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- Researchers conducted a study on vocabulary development in children, looking specifically at how genetic factors influence both expressive and receptive vocabulary sizes as children grow.
- The study involved nearly 38,000 parental reports from children of European descent and analyzed vocabulary measures at different developmental stages, assessing various genetic correlations.
- Findings indicated that early vocabulary is somewhat heritable and that there's genetic overlap with literacy skills, but a strong link to intelligence and ADHD appears later during toddlerhood.
Castration-resistant prostate cancer (CRPC) remains an incurable and lethal malignancy. The development of new CRPC treatment strategies is strongly impeded by the scarcity of representative, scalable and transferable preclinical models of advanced, androgen receptor (AR)-driven CRPC. Here, we present contemporary patient-derived xenografts (PDXs) and matching PDX-derived organoids (PDXOs) from CRPC patients who had undergone multiple lines of treatment.
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