Comparison of the Results of Modeling Pulmonary Fibrosis in Sprague Dawley Rats by Intratracheal Administration of Bleomycin in the Form of Sulfate and Chloride at a Dose of 3 mg/kg.

: Intratracheal administration of bleomycin (BLM) to laboratory rodents is a standard, widely used technique used to model pulmonary fibrosis (PF). BLM, as a modeling agent, is produced mainly in the form of two salts-sulfate and chloride. We compared the results of modeling PF in SD rats by intratracheal administration of BLM sulfate and BLM chloride.

Collisions and Perceptions of Cyberbullying: Comparison of Intergenerational Experiences.

With regard to negative consequences, cyberbullying is recognized as one of the most traumatic types of cyber aggression. The aim is to study the specific features of adolescents and youth's cyberbullying experience in the role of an aggressor, victim or bystander, as well as awareness on the part of parents of adolescents. A total of 3395 adolescents, youth and parents filled out specially designed questionnaires.

C-Terminal Region of Caveolin-3 Contains a Stretch of Amino Acid Residues Capable of Diminishing Symptoms of Experimental Autoimmune Encephalomyelitis but Not Rheumatoid Arthritis Modeled in Rats.

A short synthetic peptide from the C-terminal part of the caveolin-3 structure was tested for experimental autoimmune encephalomyelitis (EAE) treatment in rats. The structure-function similarity established between the novel synthetic peptide of pCav3 and the well-known immunomodulator immunocortin determined pCav3's ability to reduce EAE symptoms in Dark Agouti (DA) rats injected with pCav3 (500 µg/kg). pCav3 was found to interfere with the proliferation of lymphocytes extracted from the LNs of DA rats primed with homogenate injection, with IC = 0.

Multitasking as a Personal Choice of the Mode of Activity in Russian Children and Adolescents: Its Relationship to Experimental Multitasking and its Effectiveness.

Background: A person's ability to solve several tasks simultaneously, or within a limited amount of time, - , multitasking - is becoming more and more highly valued in society, despite experimental data in cognitive science about the low effectiveness of such activity. But, in the modern world, the term multitasking has become increasingly used in another sense - that is, a personal choice to perform several tasks simultaneously even if a person could do them consecutively.

Objective: The aim of this study was to reveal the relationship between a personal preference for multitasking, its subjective effectiveness in children and adolescents, and their tendency for and efficacy of multitasking under experimental conditions.

Derinat has an immunomodulatory and anti-inflammatory effect on the model of acute lung injury in male SD rats.

To simulate acute lung injury (ALI) in SD male rats they we administered intratracheally with lipopolysaccharide (LPS) followed by hyperventilation of the lungs (HVL), which lead to functional changes in the respiratory system and an increase in the blood serum concentration of inflammatory cytokines. LPS + HVL after 4 h lead to pronounced histological signs of lung damage. We have studied the effectiveness of Derinat when administered intramuscularly at dose of 7.