Synthesis of Diketohexenoic Acid Derivatives by Alkenylation of Indoles and Pyrroles with 4-Pyrones.

A new synthesis of functionalized (Z)-6-hetaryl-2,4-dioxo-5-hexenoic acids based on acid-catalyzed alkenylation of indoles and pyrroles with derivatives of 5-substituted 4-pyrone-2-carboxylic acid in 37-82% yields has been developed. Coupling between isochelidonic acid and indoles followed by decarboxylation afforded biologically important (E)-6-indolyl-2,4-dioxo-5-hexenoic acids. These ring-opening reactions proceed with high regioselectivity through nucleophilic attack at the C-6 position of the pyrone ring.

Regional model of integrating occupational control over work condition into social hygienic monitoring system.

Existing practice implementing data obtained by occupational control and special evaluation of work conditions fails to evaluate hazardous effects caused in workers' health state by wide spectrum of risk factors such as social, ecologic, climate, etc. Widening possibilities for deeper health risk analysis can be provided by integration of laboratory and instrumental data on evaluation of hazardous and dangerous occupational factors into present systems of social hygienic monitoring. According to results of joint project within disciplinary program, Leningrad regional division of Federal Agency on sanitary epidemiologic supervision specified and implemented a regional model of integrated data base in informational funds of social hygienic monitoring.