[Volume effect and change in compressibility in intercalation of ethidium bromide and daunomycin in DNA].

A combination of high-precision and density techniques was used to investigate the binding of ethidium bromide and daunomycin to DNA. It was shown that intercalation is accompanied by a decrease in apparent volume and adiabatic compressibility of DNA, which were -28 cm3mol-1 and -20.10(-4) cm3mol-1bar-1 for binding of ethidium to DNA, and -28 cm3mol-1 and -18.