Publications by authors named "E I Kovaleva"
Article Synopsis
- The diagnosis of thyroid gland tumors is complicated, requiring specialized expertise and significant time, especially when analyzing many whole slide images from one patient.
- This paper explores using artificial intelligence, specifically a Multiple-Instance Learning model, trained on weak patient-level data from over 1100 patients to differentiate between benign and malignant cases, achieving a notable F1-Score of 0.85.
- The study highlights challenges in using real-world data, such as potential issues that could lead to model overfitting, and emphasizes that detailed annotations improve accuracy, especially in smaller datasets.
Background: Primary hyperparathyroidism (PHPT) is a endocrine disorder characterized by excessive secretion of parathyroid hormone (PTH) from parathyroid gland tumors. Parathyroidectomy (PTE) is the main treatment for PHPT, but it can lead to hypocalcemia in up to 46% of cases. Hypocalcemia is associated with seizures and life-threatening cardiac arrhythmias, and vitamin D deficiency can exacerbate PHPT severity and contribute to «hungry bones syndrome,» resulting in severe and persistent postoperative hypocalcemia.
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- Type 2 diabetes involves high blood sugar and reduced function of insulin-producing β-cells, prompting research into potential treatments.
- This study tested the effects of betulin, a natural compound from birch bark, on diabetic rats, focusing on various health parameters over a 28-day period.
- Results indicated that betulin improved blood sugar levels and reduced liver and kidney damage in diabetic rats while promoting the regeneration of β-cells, suggesting it could be a promising treatment for diabetes.
[Frequency of Ponticulus posticus and Ponticulus lateralis in patients admitted to hospital with traumatic brain injur].
Zh Nevrol Psikhiatr Im S S Korsakova
January 2024
Objective: To determine the frequency of and among patients admitted to a24-hour emergency hospital.
Material And Methods: The study included 2887 patients with a traumatic history who were admitted to the hospital for emergency reasons. This principle of sampling allowed us to exclude a high concentration of studies of patients with chronic neurological diseases, the cause of which could be symptomatic Kimmerle's anomaly (KA).
Article Synopsis
- Circadian rhythm disruption is linked to increased risk and severity of inflammatory bowel disease, as shown by previous studies highlighting its effects on intestinal inflammation in mice.
- In this experiment, male mice were divided into two groups—one exposed to circadian shifts and the other kept on a regular light-dark cycle—to assess how these changes influence gut microbiota composition.
- Results indicated that mice with disrupted circadian rhythms experienced reduced gut microbiota richness and diversity, alongside changes in specific bacterial genera, suggesting that this disruption could negatively impact gut health and colitis development.