[Changes in the opsonizing capacity of the blood serum in rats after irradiation and after a combined radiation-thermal lesion].

We studied changes in the blood serum opsonic capacity after irradiation, thermal burn, or combined radiation-thermal injuries. It was shown using chemiluminescence of macrophages, that phagocytized zymosan opsonized by the serum of control or experimental animals, and inhibition of complement-dependent reactions of opsonization was observed only after combined radiation-thermal injuries and was rather short-term. Incubation of normal macrophages with a serum obtained after the studied influences decreased the chemiluminescent response of macrophages to latex absorption.

[The modifying influence of thermal injury on the postradiation changes in the biochemical and functional activities of peritoneal macrophages].

The effect of thermal injury on radiation-induced (3-7 Gy) changes in quantitative and qualitative composition, biochemical and functional activity of the peritoneal macrophages was studied. The reduce of peritoneal cells total number and alterations of their qualitative composition were conditioned by radiation component of combined radiation end thermal injury (CRTJ). The enzymes' activity and the protein content in macrophages were the most enhanced 7-9 days after CRTJ as compared with the effect of radiation per se.

[Post-irradiation changes of metabolic and functional activity of adhesive macrophages].

Research into dose- and time-dependent alterations of quantitative and qualitative composition of the peritoneal cells has been carried out. Exposure at 3, 5, 7, or 9 Gy reduced the total number of peritoneal cells, increased the activity of the lactate-, malate-, and qlucoso-6-phosphate dehydrogenases, of the acid phosphatase and catepsin D; the amount of the cell protein in adhesing macrophages was also increased. The exposed macrophages showed enhanced phagocytic and cytotoxic activity as evidenced by the increase in luminol- and lucigenin-enhanced chemilumenscence in vitro.

[The use of preparations of protozoan origin as agents for the prevention and early therapy of combined radiation-thermal injuries].

Radioprotective and therapeutic effects of astazian and astazilide, the drugs of protozoan origin, were studied in comparison with known modifiers of biological reactions (bacterial polysaccharides, synthetic polypeptides) in combined radiation-thermal injuries (CRTI). The efficiency of drugs under examination was found to be time- and dose-dependent. Application of the drugs of protozoan nature 24 hours prior to or 1 hour following CRTI provided 30 to 50% survival of experimental animals for 30 days as compared to 4.