Publications by authors named "E I Kampylafka"
Fibroblasts are important regulators of inflammation, but whether fibroblasts change phenotype during resolution of inflammation is not clear. Here we use positron emission tomography to detect fibroblast activation protein (FAP) as a means to visualize fibroblast activation in vivo during inflammation in humans. While tracer accumulation is high in active arthritis, it decreases after tumor necrosis factor and interleukin-17A inhibition.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied circulating miRNA signatures in psoriasis and psoriatic arthritis patients to determine associations with these diseases.
- They analyzed 192 miRNAs in 48 samples using RT-qPCR, revealing significant changes in 51 miRNAs for psoriasis and 64 for psoriatic arthritis compared to healthy controls.
- The study identified nine key miRNAs that distinguished patients from controls, with four specifically differentiating psoriasis from psoriatic arthritis, suggesting a link between miRNA changes and inflammation affecting bone and cartilage.
Background: Timely diagnosis and treatment are essential in the effective management of inflammatory rheumatic diseases (IRDs). Symptom checkers (SCs) promise to accelerate diagnosis, reduce misdiagnoses, and guide patients more effectively through the health care system. Although SCs are increasingly used, there exists little supporting evidence.
View Article and Find Full Text PDFBackground: Limited information exists about the very early forms of psoriatic arthritis. In particular, differences and responsiveness of patient-reported outcomes (PROs) in very early as compared to established PsA have not been investigated to date.
Methods: Cross-sectional and prospective longitudinal evaluation of PROs related to pain (VAS), physical function (HAQ-DI, SF-36 physical), mental function (SF-36 mental), impact of psoriatic skin (DLQI), joint (PsAID), and global disease (VAS) in two small prospective observational studies on secukinumab 300 mg over 6 months in very early disease patients (IVEPSA study, N = 20) and established PsA (PSARTROS study, N = 20).
Article Synopsis
- The study investigates whether structural entheseal lesions in psoriasis patients affect the likelihood of developing psoriatic arthritis (PsA).
- A prospective cohort study was conducted with 114 psoriasis patients, tracking them over 28.2 months on average, where 24 patients went on to develop PsA.
- Results indicated that patients with these lesions had a significantly higher risk of developing PsA, and higher cortical volumetric bone mineral density (vBMD) at entheseal sites correlated with a reduced risk of progression to PsA.