[Muscle atrophy in microgravity and during its simulation].

Summarized are the results of comparative analysis of morphological changes in rat's skeletal muscles after microgravity and its simulation. On completion of space flight, hindlimb muscles of rats exhibited atrophy developed in space microgravity in consequence of the lack of weight-bearing loads and changes solely in the slow anti-g muscles due to the hemodynamic disorders appearing after space flight. Immobilization combined with clinostatting cannot be a veridical laboratory model of microgravity, as horizontally positioned animals still possess weight and, besides, experience severe chronic stress of immobilization.

[Dynamics of rat's soleus muscle recovery from the suspension-induced atrophy].

Dynamics of the 60-d soleus recovery was studied morphologically and histomorphometrically in female rats exposed to 30-d tail-suspension. Suspension led to soleus atrophy manifested by substantial losses in mass (56% vs. the control) and cross-sectional area of myofibers, and partial transformation of slow fibers into fast.

[Effects of ibandronate on the osteopenia process in tail-suspended rats].

Histological and histomorphometric effects of ibandronate on the metaphyseal spongiosis in tibia were studied in tail-suspended rats and their controls in a 30-d experiment. Ten- to twenty-day course of ibandronate at a dose of 6 micrograms/kg of the body mass per diem altered the architectonics of metaphyseal spongiosis and increased materially the total spongiosis volume no matter whether those were suspended rats or controls. Spongiosis growth was a result of a sharp deterioration of resorption and spongy bone remodelling due to ibandronate.

[The effect of retabolil and support loads on atrophied muscles in suspended rats].

In experiments with rats histological and morphometric methods were employed to study effects of anabolic steroid rhetabolil and a combination of rhetabolil with predetermined support loads on development of atrophy in m. soleus and m. gastrocnemius.

[Characteristics of the post-traumatic reparative process in the M. soleus of rats subjected to extended suspension].

Histological methods were applied to study the course of post-traumatic reparation of m. soleus in rats subjected to a 30-d head-down suspension. Muscles in unconscious animals were traumatized on day 15 of suspension by crushing a small part with the artery clamp.