Publications by authors named "E I Grishina"
The introduction of faricimab, a drug targeting both vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2, has enabled the implementation of the highly effective dual inhibition strategy in real clinical practice for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME), both previously treated with intravitreal injections and newly diagnosed. This article presents a series of 11 clinical cases involving patients with nAMD and DME who received loading doses of faricimab and continued ophthalmological observation. Among them, three patients with nAMD and two with DME were treatment-naïve, while the others were switched from alternative therapies to faricimab.
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- The study examines hospital records of Crohn's disease patients over six years to understand patterns in emergency admissions, surgical needs, and lesion locations.
- It includes a thorough analysis of surgical cases, clinical data, and the time taken from symptoms to diagnosis.
- Findings suggest that longer diagnostic delays can lead to more complications and a higher likelihood of needing surgery for these patients.
Article Synopsis
- - Dry eye disease (DED) is primarily caused by inflammation on the surface of the eye, and treating it effectively starts with early anti-inflammatory medications like cyclosporine A (CsA).
- - There is a lack of comprehensive recommendations for how to use topical CsA in treating DED in real-world clinical settings.
- - The article provides expert consensus on practical guidelines for DED management, covering when to start CsA, how long to use it, comparing CsA products approved in Russia, and the importance of educating patients.
Ischemic heart disease, which is often associated with irreversibly damaged heart muscle, is a major global health burden. Here, we report the potential of stem cell-derived committed cardiac progenitors (CCPs) have in regenerative cardiology. Human pluripotent embryonic stem cells were differentiated to CCPs on a laminin 521 + 221 matrix, characterized with bulk and single-cell RNA sequencing, and transplanted into infarcted pig hearts.
View Article and Find Full Text PDFgene polymorphisms influence on antihypertensive effectiveness and hypouricemic effect of losartan among patients with arterial hypertension: an observational study.
Drug Metab Pers Ther
June 2023
Objectives: gene polymorphic variants can decrease the effects of losartan, reducing active metabolite (E-3174) formation. Study aims to determine the influence of (+430C>T; rs799853) and *3 (+1075A>C; rs1057910) gene polymorphic variants on the hypotensive and uricosuric effect of losartan on patients with arterial hypertension.
Methods: Eighty one patients with stage 1-2 arterial hypertension newly diagnosed with ABMP were enrolled in the study.