Responses of Blood System to Doxorubicin/Docetaxel Chemotherapy in Patients with Breast Cancer.

We studied the effects of combined chemotherapy with doxorubicin/docetaxel on erythroid and granulocytic hematopoietic lineages with particular attention focused on their recovery in patients with stages III-IV breast cancer. Intensification of differentiation of erythroid and granulocytic CFU (even under conditions of their suppressed proliferation) provided the increase in the content of mature and morphologically differentiated elements in the bone marrow and peripheral blood. High proliferative activity of erythroid and granulomonocytic precursors resulted from enhanced production of hematopoiesis-stimulating activities by microenvironment elements.

[The possibilities for the prevention of incompetent tracheorrhaphy].

The present review of the literature is focused on the methods designed for the prevention of incompetent tracheorrhaphy. The main cause that dictates the necessity of strengthening the sutures is the risk of the development of the complications during the postoperative period following the surgical interventions. The incompetence of the tracheal anastomoses is known to occur in 3.

THE PREDICTIVE SIGNIFICANCE OF A MALLAMPATI SAMSOON & YOUNG SCORE AT OPERATIONS IN NOSE AND NASOPHARYNX AT CHILDREN.

Background: The difficult airways at children happen rarely, but can lead to serious complications.

Materials And Methods: Results of studying of sensitivity, specificity and predictive importance of a scale of Mallampati at 379 children aged from 3 till 17 years (ASA physical status I-II), who underwent surgery in the nasal cavity and nasopharynx, are presented in this article. Depending on result of Mallampati's score children have been distributed on 2 groups.

[PREEMPTIVE ANALGESIA AS PART OF MULTICOMPONENT ANESTHESIA IN CHILDREN WITH OPERATIONS IN THE NASAL CAVITY AND NASOPHARYNX].

Objective: The article presents the results of assessing the impact of pre-emptive analgesia with lidocaine and paracetamol compared withfentanyl for postoperative pain in children undergoing surgery for nasal cavity and nasopharynx.

Methods: We evaluated the incidence and severity ofpostoperative pain in 150 patients aged 3 to 17 years (ASA I-II), following operations in the nasal cavity and nasopharynx.

Results: In pre-emptive analgesia group, patients (n = 75) experienced postoperative pain at 28% less in comparison with the control group.